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Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice

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The present study investigated the antiaging effects of pomegranate juice concentrated powder (PCP) in hairless mice following 15 weeks of UVB irradiation (three times a week; 0.18 J/cm2). Skin moisturizing effects were evaluated through skin water, collagen type I and hyaluronan contents, as well as collagen type I and hyaluronan synthesis-related transcript levels. Wrinkle formation and edema scores (skin weights) were also assessed, along with skin matrix metalloproteinase (MMP)1, MMP9 and MMP13 transcript levels. To determine the antiinflammatory effects of PCP, myeloperoxidase (MPO) activity, interleukin (IL)1β and IL10 contents were observed. Caspase3 and cleaved poly(ADP-ribose) polymerase (PARP) were used as an apoptotic index in epidermal keratinocytes. To determine the antioxidative effects of PCP, nitrotyrosine and 4hydroxynonenal immunoreactive cells were detected and glutathione (GSH) content, malondialdehyde levels, superoxide anion production, Nox2, and GSH reductase mRNA expression were all measured. The results indicated that skin wrinkles induced by photoaging were significantly reduced by PCP, whereas skin water contents, collagen type I and hyaluronan contents all increased. Furthermore, IL1β levels in the PCPtreated groups were lower than those in the UVBexposed control group. UVBinduced GSH depletion was also inhibited by PCP. Taken together, the results of the current study suggest that PCP has favorable protective effects against UVBinduced photoaging through antiapoptotic effects, MMP activity inhibition and ECM (COL1 and hyaluronan) synthesisrelated moisturizing, antiinflammatory and anti-oxidative effects.
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Document Type: Research Article

Affiliations: 1: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbukdo 38610, Republic of Korea 2: Research Institute, HealthLove Co., Ltd., Anyang, Gyeonggido 13946, Republic of Korea

Publication date: August 1, 2017

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  • Experimental and Therapeutic Medicine aims to ensure the expedient publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and studies relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease are also included.

    All materials submitted to this journal undergo the appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regard to approval of experiments on humans and animals.
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