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Effects of glutamine on markers of intestinal inflammatory response and mucosal permeability in abdominal surgery patients: A meta-analysis

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The present meta-analysis was carried out to determine whether supplementation with glutamine (Gln) would reduce the intestinal inflammatory response and mucosal permeability in patients undergoing abdominal surgery. The PubMed, EMBASE, Web of Science, and The Cochrane Library databases were searched for randomized controlled trials on the effects of supplementation with Gln, and published from August, 1966 to June 2014. Inclusion criteria for the meta-analysis were: i) Study design was a randomized controlled trial, ii) study included patients undergoing abdominal surgery, iii) study patients received a supplementation with Gln peptide (AlaGln or GlyGln) whereas control patients did not use any supplements, and iv) study outcomes included inflammatory markers [Creactive protein (CRP), tumor necrosis factorα (TNFα), and interleukin (IL)6, and IL2 receptor] and markers of intestinal permeability [lactulose/mannitol, diamine oxidase, D()lactic acid, and endotoxin]. Qualities of controlled trials were assessed using the Jadad score. Metaanalyses were performed with fixed or randomeffect models depending on the heterogeneity of studies. There were 21 trials meeting the inclusion criteria. The metaanalysis revealed that the levels of CRP, TNFα, and IL6 in patients supplemented with Gln were significantly lower than those in control patients, whereas the levels of IL2 receptor were increased by Gln supplementation. Gln also significantly decreased the lactulose/mannitol ratio, the levels of diamine oxidase and endotoxin, and tended to decrease the levels of cyclic Dlactic acid. In conclusion, Gln appears to effectively reduce the inflammatory response and intestinal mucosal permeability in patients after abdominal surgery.
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Document Type: Research Article

Affiliations: 1: Department of Nutrition, Jinshan Hospital, Fudan University School of Medicine, Shanghai 201508, P.R. China 2: Tongji University School of Medicine, Shanghai 200092, P.R. China

Publication date: January 1, 2016

More about this publication?
  • Experimental and Therapeutic Medicine aims to ensure the expedient publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and studies relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease are also included.

    All materials submitted to this journal undergo the appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regard to approval of experiments on humans and animals.
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