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Association between low expression levels of interleukin-9 and colon cancer progression

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Although interleukin (IL)-9 has been extensively studied in inflammation and autoimmune diseases, the expression level of IL9 in colon cancer and its clinical significance are less well established. In total, 15 healthy donors (HDs) and 60 patients who had been diagnosed with colon cancer that had undergone a surgical resection were enrolled in the study. The plasma levels of IL9 in the HDs and cancer patients were detected by the liquid chip technique, while the expression levels of IL9 in the colon cancer tissues and normal tissues were analyzed using immunohistochemistry (IHC) and reverse transcriptionquantitative polymerase chain reaction (RTqPCR). Finally, the difference in the expression levels of IL9 between the patients classified as tumornodemetastasis stage  and stage  was compared. The results demonstrated that the plasma levels of IL9 in the patients with colon cancer were significantly lower when compared with the HDs (1.29 vs. 2.53 pg/ml, P<0.05). Furthermore, according to the IHC and RTqPCR results, low expression levels of IL9 were observed in the colon cancer tissues when compared with the normal tissues (P<0.05). With regard to the plasma and tumor tissue samples, patients diagnosed with stage  colon cancer expressed lower levels of IL9 compared with the stage  patients (P<0.05). In conclusion, low expression levels of IL9 were observed in the tissue and plasma samples collected from the colon cancer patients, and the decreased expression of IL-9 was shown to correlate with colon cancer progression.
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Document Type: Research Article

Affiliations: 1: Department of Gastroenterological Surgery, Cancer Center of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China 2: Department of Colorectal and Anal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China

Publication date: January 1, 2015

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  • Experimental and Therapeutic Medicine aims to ensure the expedient publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and studies relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease are also included.

    All materials submitted to this journal undergo the appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regard to approval of experiments on humans and animals.
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