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Open Access Tumour microenvironment-targeted therapy focused on the IGF activation mechanism

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Cancer treatment has greatly improved over the past few decades; and there is much to be optimistic about. However, there are still many challenges facing researchers and the medical community in regards to how they treat cancer sufferers. Scientists around the world continue to investigate cancers in order to continue to improve treatments and to better our understanding of the various mechanisms associated with cancer, especially 'metastasis'. Dr Shin'ichi Miyamoto (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University) is leading a team investigating the mechanisms by which cancer cells adapt to their microenvironment in a metastatic organ. One of the main areas the team focuses on is concerned with Insulin-like growth factors (IGFs). They clarified that tumour-derived matrix metalloproteinase-7 (MMP-7) could degrade all six IGF binding proteins (physiological inhibitory factors of IGF) and speculated that it acts as IGF activators in all processes from carcinogenesis to metastasis everywhere in which all IGF-IGFBP complexes exist. This IGF activation model by MMP-7 strongly suggests the usefulness of IGF as a therapeutic target in IGFBP ptotease-producing cancers.
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Keywords: INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR BINDING PRTEIN PROTEASES; MATRILYSIN; MATRIX METALLOPROTEASE-7; MOLECULAR-TARGETED THERAPY; TUMOR MICROENVIRONMENT

Document Type: Research Article

Publication date: November 1, 2019

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