@article {Ueha:2019:2398-7073:68,
title = "Molecular mechanism of smoking smell and elucidation of regeneration environment of olfactory epithelium",
journal = "Impact",
parent_itemid = "infobike://sil/impact",
publishercode ="sil",
year = "2019",
volume = "2019",
number = "6",
publication date ="2019-06-05T00:00:00",
pages = "68-70",
itemtype = "ARTICLE",
issn = "2398-7073",
eissn = "2398-7081",
url = "https://www.ingentaconnect.com/content/sil/impact/2019/00002019/00000006/art00025",
doi = "doi:10.21820/23987073.2019.6.68",
keyword = "MUCOSAL INFLAMMATION, OLFACTORY MECHANISMS, OLFACTION, CIGARETTE SMOKE, SMOKING, INFLAMMATORY CYTOKINES, DEVELOPMENT OF NEURODEGENERATIVE DISEASES, TOXIC CHEMICAL EXPOSURE, OLFACTORY EPITHELIUM, AGEING, OLFACTORY RECEPTOR NEURONS, OLFACTORY PROGENITOR CELLS, DETERIORATION OF OLFACTORY DISORDER",
author = "Ueha, Rumi",
abstract = "Research by Assistant Professor Rumi Ueha takes into consideration a range of environmental factors affecting the sense of smell, including age, inflammation and cigarette smoke. She highlights: 'Significant oxidation occurs to human beings exposed to daily life-creating stress and
chronic rhinitis in the nasal region, and smoking is involved in the onset and deterioration of olfaction.' Risk factors for the onset of chronic nasal and secondary nasal disorders affect sense of smell by impairing the olfactory epithelium and changing the flow of air that exacerbates mucous
membrane inflammation of the cavity, resulting in both breathing and olfactory disorders. Olfactory disorders can occur as a result of a variety of factors ranging from ageing to toxic chemical exposure, airway allergies, upper-airway viral infections, head trauma or development of neurodegenerative
diseases, and in most cases loss of olfactory senses is a characteristic symptom. With an ageing population and increasing incidences of respiratory infections and asthma, as well as allergy related illnesses such as rhinitis, it is becoming increasingly important to understand the molecular
mechanism of the pathology and understand the impact of upper respiratory tract infections as a result of environmental factors such as smoking. Ueha outlines three key objectives to her research: 'The objectives are to understand at the molecular level the effect of cigarette smoke on olfactory
mechanisms, to assess how smoking can influence olfactory epithelium homeostasis and epithelial disorder recovery process, and determine how the age of patients can influence inflammation and recovery.' The analysis will focus on histological analysis of changes to cells at the molecular level",
}