Study on β-cell regeneration and protection of acinar like cell group (ATLANTIS) in contact with pancreatic islets
Dr Kobayashi is the director of the Okinaka Memorial Institute for Medical Reserch and former Professor of Department of Internal Medicine III at the Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo in Japan. With a solid background in the
immune processes of beta cell destruction and restoration in Type 1 diabetes he is leading a team of scientists delving into some of the key processes involved in beta cell restoration. Kobayashi's research has facilitated the discovery of distinct acinar-like clusters (ATLANTIS) that adhere
directly to islet cell clusters by a common basement membrane. 'Prior to our discovery of ATLANTIS, the islet was considered to be independent from exocrine tissue,' explains Kobayashi. 'In fact, textbooks also used to state that this cluster was isolated from exocrine tissue through the basement
membrane. Our crucial finding is that the exocrine-like cell cluster (ATLANTIS) is conjugated with the islet and that the two cell masses are covered with a common basement membrane, it is an anatomical finding.' This finding has triggered a deeper interest in ATLANTIS because these cells
possess and secrete the regenerating gene protein (REG) that promotes the regeneration of beta cells, which is a turning point towards curing Type 1 diabetes.
Keywords: ACINAR-LIKE CELL CLUSTERS (ATLANTIS); BETA CELLS; BLOOD GLUCOSE LEVELS; HYPERGLYCAEMIA; PANCREAS; REGENERATING GENE PROTEIN (REG); TYPE 1 DIABETES
Document Type: Research Article
Publication date: 01 June 2019
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