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Open Access Development of diabetes drug treatment for shift workers: Modelling of fluctuating treatment effect

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The current study involving the effects of light on diabetes drugs is essential in beginning to gather data on dosage regimens that can adequately treat diabetes for individuals whose biological rhythms are constantly in flux due to erratic environmental changes. Miyazaki's research requires the construction of an experimental model that will allow him to investigate the effects of light on medication. He and his team plan to alter the light environment for rats during an eight-hour time span and will determine the daily PK-PD relationship that results from this change. After exposing the rats to the equivalent of shift work's alterations of daylight, Miyazaki will measure PK-PD relationships on the first, second, third, sixth and twelfth day following the shift simulation. He and his team will document all factors relating to the experiment, including dose each day and hypoglycaemic effect. 'If I shift the light environment repeatedly every two days as in the actual shift work, I think that by accumulating the PK-PD relationship on the second day, I might estimate the time courses of plasma glucose concentration on an arbitrary day in shift work,' states Miyazaki. He adds: 'if it is possible to clarify the PK-PD relationship and model it further, it should be possible to simulate the pharmacological effects and side effects when a drug is administered under various conditions. From this simulation, we can obtain clues to help us develop an optimal dosage regimen'. Therefore, by modelling biological rhythm variations and noting pharmacological effects, Miyazaki and his colleagues will be on the way to uncovering suitable drug treatment options for diabetic shift workers. While Miyazaki expected that light environment would affect PK-PD relationship, the results of his studies thus far have proven even more pronounced than he expected. Preliminary work has shown that light exposure dramatically alters drug movement and effect.
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Keywords: BIOLOGICAL RHYTHMS; CIRCADIAN RHYTHM; DAILY PK-PD RELATIONSHIP; DESYNCHRONIZATION; DIABETES TREATMENT; DIABETIC SHIFT WORKERS; DOSAGE REGIMENS; EFFECTS OF LIGHT ON DIABETES DRUGS; EFFECTS OF LIGHT ON MEDICATION; ENVIRONMENTAL CHANGES; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMA GLUCOSE CONCENTRATION; SHIFT WORK

Document Type: Research Article

Affiliations: Osaka University of Pharmaceutical Sciences, Japan

Publication date: April 1, 2019

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