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Open Access Unveiling the Mystery of Psychosis Using Synchrotron Radiation

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Intelligence resides in the brain. The mystery of intelligence of human beings can therefore be revealed only by analyzing the neuronal network of human brain tissue. The Mizutani Laboratory team of Tokai University receiving research grants from the Japan Society for the Promotion of Science studies human brain tissues including those of schizophrenia sufferers with x-ray nanotomography (nano-CT) and microtomography (micro-CT). The work is being carried out as a collaboration with synchrotron radiation facilities SPring-8 of Japan and Advanced Photon Source (APS) in the United States. While there are existing techniques within 3D imaging, Mizutani clarifies that they cannot visualise human brain tissues exactly and hence lack the necessary detail around the 3D cellular and subcellular structures. The nano-CT method that the team uses in their research can (1) visualize opaque objects such as brain tissue, (2) at 3D isotropic nanometer resolution (3) without any image deformation. These three advantages are essential in getting the real 3D image of neurons. The researchers also developed a method for building Cartesian coordinates models of the tissue structure, that allowed detailed analysis of brain tissue to determine differences between individuals. 'By using synchrotron radiation nano-CT and by analyzing the structure in the Cartesian coordinate space, the detail that is uncovered has never been seen before,' he observes.
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Document Type: Research Article

Publication date: March 1, 2019

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