Skip to main content
padlock icon - secure page this page is secure

Open Access Novel structure development of vitamin D-derived photoreactive isomers: development of bone effect enhancement and half-life extension molecules in vivo

Download Article:
 Download
(PDF 161.5 kb)
 
Towards the development of vitamin D-derived photoreactive isomers in an effort to remove the side effects traditionally associated with vitamin D medicines.

Despite the enormous benefits of active vitamin D, its therapeutic application is not without its problems. For instance, the pharmacological doses of active vitamin D required for cancer chemotherapy induce serious side effects, including hypercalcemia (where the calcium level in your blood is above normal) and hyperphosphatemia (where there is an abnormally elevated level of phosphate in the blood). However, it is worth noting that vitamin D supplementation is not a bad thing for humans, as the active vitamin D formation is strictly regulated by blood calcium level, parathyroid hormone and calcitonin.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Keywords: 2FI-FUNCTIONAL GROUP; ALTERNATIVE BINDING MODE; AMINO ACID RESIDUES; BLOOD CALCIUM LEVEL; CALCITONIN; CANCER CHEMOTHERAPY; HYPERCALCEMIA; HYPERPHOSPHATEMIA; LIGAND BINDING DOMAIN (LBD); PARATHYROID HORMONE; SYNTHETIC LIGAND; TERMINAL HYDROXY GROUP; VITAMIN D ANALOGUES; VITAMIN D MEDICINES; VITAMIN D RECEPTOR (VDR); VITAMIN D-DEPENDENT TRANSCRIPTIONAL FACTOR; VITAMIN D-DERIVED PHOTOREACTIVE ISOMERS

Document Type: Research Article

Publication date: December 1, 2018

More about this publication?
  • Impact is a series of high-quality, open access and free to access science reports designed to enable the dissemination of research impact to key stakeholders. Communicating the impact and relevance of research projects across a large number of subjects in a content format that is easily accessible by an academic and stakeholder audience. The publication features content from the world's leading research councils, policy groups, universities and research projects. Impact is published under a CC-BY Creative Commons licence.

  • Subscribe to this Title
  • Terms & Conditions
  • Disseminating research in Impact
  • Information about Impact
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more