Novel structure development of vitamin D-derived photoreactive isomers: development of bone effect enhancement and half-life extension molecules in vivo
Despite the enormous benefits of active vitamin D, its therapeutic application is not without its problems. For instance, the pharmacological doses of active vitamin D required for cancer chemotherapy induce serious side effects, including hypercalcemia (where the calcium level in your blood is above normal) and hyperphosphatemia (where there is an abnormally elevated level of phosphate in the blood). However, it is worth noting that vitamin D supplementation is not a bad thing for humans, as the active vitamin D formation is strictly regulated by blood calcium level, parathyroid hormone and calcitonin.
Keywords: 2FI-FUNCTIONAL GROUP; ALTERNATIVE BINDING MODE; AMINO ACID RESIDUES; BLOOD CALCIUM LEVEL; CALCITONIN; CANCER CHEMOTHERAPY; HYPERCALCEMIA; HYPERPHOSPHATEMIA; LIGAND BINDING DOMAIN (LBD); PARATHYROID HORMONE; SYNTHETIC LIGAND; TERMINAL HYDROXY GROUP; VITAMIN D ANALOGUES; VITAMIN D MEDICINES; VITAMIN D RECEPTOR (VDR); VITAMIN D-DEPENDENT TRANSCRIPTIONAL FACTOR; VITAMIN D-DERIVED PHOTOREACTIVE ISOMERS
Document Type: Research Article
Publication date: December 1, 2018
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