Research undertaken in the Hibino Lab - analysis of the cochlear machineries underlying establishment of normal hearing
A fundamental gap in our understanding of the physiological problems that can occur in the ear is our knowledge of the mechanisms of the sound signal transduction. This forms part of the scope of Hibino's work; in particular, he is focused on analysis of the mechanisms behind the unique electrochemical properties of the cochlear endolymph. This is because the balance of potential and ions in the endolymph is fundamental to whether or not the inner hair cells depolarise and send a signal. The endolymph is highly positively charged, with transport of potassium ions (K+). It is suspected that potassium ion circulation is key to proper function, as those with hereditary deafness have mutations in the genes for potassium ion transporters and channels. In order to investigate this in more detail, Hibino and his team are employing microelectrodes capable of measuring both the electrical potential of the endolymph and the potassium ion concentration.
Keywords: COCHLEA; DEAFNESS; DRUG TRACKING IN VIVO; ELECTROCHEMICAL PROPERTIES OF THE COCHLEAR ENDOLYMPH; ELECTROCHEMICAL SENSOR; HEREDITARY DEAFNESS; IMPAIRED HEARING; INNER EAR; INNER HAIR CELLS; MATHEMATICAL MODEL; MICROELECTRODES; POTASSIUM ION CIRCULATION; POTASSIUM ION CONCENTRATION; POTASSIUM ION TRANSPORTERS AND CHANNELS; POTASSIUM IONS (K+); SENSORINEURAL HEARING LOSS; SOUND SIGNAL TRANSDUCTION
Document Type: Research Article
Publication date: October 15, 2018
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