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Open Access Breast cancer therapeutics with Vif - FCT Project PTDC/BIM-MAC/66312014

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Breast cancer is the most common malignancy in women around the world and, in spite of impressive advances in early detection and also in understanding the molecular basis of breast cancer biology, around 30 per cent of patients with early-stage breast cancer has recurrent relapses. One team of researchers is working tirelessly to develop therapies for the disease by better understanding the molecular characteristics of these tumours. They are focusing their efforts on investigating APOBEC3 as a target to improve treatment.

Isabel Barahona is heading up the 'Breast cancer therapeutics with VIF' project. The laboratory work surrounds exploring the different aspects of HIV-2 infections, explaining the importance of VIF (Virion infectivity factor) to avoid cancer progression and resistance to chemotherapy, and developing cytotoxicity studies using several dental materials, which is being done with Master's students. It is being conducted in a private institution in Portugal, recently considered a university institution with public interest and renamed as Instituto Universitário Egas Moniz (IUEM). Barahona has been active in this field of research since 1993, when she left Instituto Gulbenkian de Ciência and joined the microbiology group in the Faculty of Pharmacy at the University of Lisbon that was working on characterising different aspects of HIV-2 infection. She is collaborating with the Instituto de Medicina Molecular (iMM Lisboa) via Evguenia Bekman, with the Faculty of Pharmacy through João Gonçalves and also has support from laboratories outside of Portugal; for example, with Klaus Strebel.
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Keywords: APOBEC3; BREAST CANCER; CANCER THERAPEUTICS; HIV; VIF

Document Type: Research Article

Publication date: October 15, 2018

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