Personalised medicine for biliary tract and pancreatic cancers
The teams are taking a four-step process to research this area, with a view to identifying new therapies that can target individual cancers. The first step is to continue to culture organoid models of the cancers for study and drug screening. Secondly, a range of analyses will be undertaken on these models, by both teams, to identify stage-specific biomarkers of diseases. In the third stage, the identified molecular epigenomic and genetic biomarkers will be validated using CRISPR/Cas9 editing to develop disease models in organoids and mice. Lastly, these models and those developed from patients' own tumour samples will be used to screen drugs for personalised therapy.
Document Type: Research Article
Publication date: October 15, 2018
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