Establishment of a secure differentiation and de-differentiation-inducing method by protein transduction system LENA
For the last three years, Dr Jun Komano, Head of the Clinical Laboratory at Nagoya Medical Centre in Japan, has been working to perfect a method of changing cell DNA, which he hopes will avoid some of the downsides associated with other methods of gene editing. The LENA project achieves protein transduction using a pseudo-typed lentivirus nano-particle, which promises to be a safer method for cell fate redirection and gene-editing. He points out: 'a technology to deliver gene editing in a highly regulated manner, without damaging the host cell genome and predisposing cells to becoming malignant, is necessary for gene therapy to become a practical and effective means of treating disease in the clinic.'
Document Type: Research Article
Publication date: March 1, 2018
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