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Open Access Elucidation of the molecular mechanism of disease development due to calpain dysfunction – CALPAIN

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The CALPAIN project aims to unravel the complexity of calpain molecules and, in turn, use their discoveries to generate effective drugs and therapies for calpain-related diseases. Along with studying the basic structure and function of a calpain, researchers are working to unravel the molecular mechanisms behind calpain-related diseases. By discovering the pathology of these diseases, members of the CALPAIN project can aid in the development of novel strategies for predicting, preventing, diagnosing and treating various disorders.

In an effort to further scientific understanding of calpains and their vital biological roles, the CALPAIN project was established within the Tokyo Metropolitan Institute of Medical Science in Japan. Led by Department Head Dr Hiroyuki Sorimachi, the CALPAIN project's goals include analysing the mechanisms of calpains at a molecular level; clarifying their physiological functions; analysing diseases marked by calpain deficiency using genetically-modified mice; and developing future diagnosis and treatment plans for calpain-related diseases.
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Keywords: CALPAIN; CALPAIN FAMILY; CALPAINOPATHIES; MODULATOR PROTEASE; MOLECULAR MECHANISMS; PHYSIOLOGICAL FUNCTIONS OF CALPAINS; PROTEOLYSIS; SUBSTRATE SPECIFICITY

Document Type: Research Article

Publication date: March 1, 2018

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