Skip to main content
padlock icon - secure page this page is secure

Open Access Neural mechanism of central post-apoplectic pain: experimental study of P2X7 receptor and BDNF

Download Article:
 Download
(PDF 350.1 kb)
 
Central post-stroke pain (CPSP) refers to pain resulting from a primary lesion or dysfunction of the central nervous system after a stroke. Stroke in the thalamus is one of the most common causes of neuropathic central pain. The lesions anywhere in the spinothalamocortical pathway lead to prominent over-activity of the lateral thalamus. These patients suffer from allodynia and hyperalgesia after stroke, which are among the most troublesome post-stroke sequelae (consequences). The distribution of pain ranges from small to large areas and is often described as long-lasting, severe and persisting. It can also be spontaneous or evoked. The intensity of spontaneous pain often fluctuates and can be increased by internal or external stimuli, such as stress or cold. Symptoms therefore interfere with sleep and reduce quality of life. Pain caused by CPSP results from a primary lesion or dysfunction of the central nervous system after stroke. More specifically, strokes located in the thalamus are one of the most common causes of neuropathic pain. A stroke causes local tissue damage and inflammation at its site. This leads to the onset of nociceptive pain, which is pain resulting from the stimulation of nerve cell. This stimulation and subsequent hyperactivity of the brain region is the root cause of the pain, but it is poorly understood which molecular pathways are involved in firing of the stimulated cells. Recent evidence, however, has suggested the involvement of ion channels and adenosine triphosphate (ATP) gated cation channel P2X receptors. The involvement of these channels and receptors means the molecules that activate and pass through them, various cytokines and proteins, have the potential to be used to indicate that the nociceptive pain pathway is being activated. One researcher attempting to unravel the mysteries surrounding CPSP is Dr. Bai Chuang Shyu, along with his team at the Institute of Biomedical Sciences, Academia Sinica in Taiwan. His work has focused on the neuronal mechanisms underlying this condition. 'The purpose of our study is to draw attention to the importance of this 'hidden' disorder and place it within the context of central neuropathic pain,' he explains. In order to do so, Shyu is searching for biomarkers for early diagnosis of CPSP, as well as working on the development of a therapeutic strategy.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Keywords: AFFECTIVE/EMOTIONAL ASPECT OF ACUTE AND CHRONIC PAIN; CENTRAL POST-STROKE PAIN (CPSP); MEDIAL PAIN SYSTEM; NEURONAL MECHANISMS; NEUROPATHIC PAIN; NOCICEPTIVE MECHANISM; POST-STROKE PAIN; STROKE; THALAMOCINGULATE NETWORK ACTIVITIES

Document Type: Research Article

Publication date: November 1, 2017

More about this publication?
  • Impact is a series of high-quality, open access and free to access science reports designed to enable the dissemination of research impact to key stakeholders. Communicating the impact and relevance of research projects across a large number of subjects in a content format that is easily accessible by an academic and stakeholder audience. The publication features content from the world's leading research councils, policy groups, universities and research projects. Impact is published under a CC-BY Creative Commons licence.

  • Subscribe to this Title
  • Terms & Conditions
  • Disseminating research in Impact
  • Information about Impact
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more