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Open Access Integrated understanding of temperature-dependent biological phenomena

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This inter-disciplinary research project will investigate temperature-sensing mechanisms and their involvement across a wide range of biological responses and from molecular to whole organism levels. The project will consider two subgroups, 'A01: temperature sensing' and 'A02: temperature-responding systems' to clearly address the questions of how temperature is sensed and how temperature is related to biological functions, respectively.

'A01: temperature sensing' addresses temperature sensing mechanisms by focusing on plasma membrane molecules, intracellular molecules and intracellular metabolic pathways. 'A01' also seeks to develop ways to detect and regulate local temperatures at a cellular level, which would facilitate future temperature-sensing research.

'A02: temperature-responding systems' will focus on the neural circuits that integrate information concerning ambient temperature sensation, the effects of temperature on metabolic functions and biological rhythms, and mechanisms involved in emotion formation. 'A02' also clarifies crosstalk between temperature-responding systems by developing methods to detect and regulate local temperatures in organs. Comprehensive collaborations among the research groups will further enhance the progress of each research project.
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Keywords: INTRACELLULAR METABOLIC PATHWAYS; INTRACELLULAR MOLECULES; PLASMA MEMBRANE MOLECULES; TEMPERATURE-DEPENDENT BIOLOGICAL PHENOMENA; TEMPERATURE-SENSING MECHANISMS

Document Type: Research Article

Publication date: 01 May 2017

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