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Open Access Content loaded within last 14 days PeBiToSens™: A Platform for PBT Screening of Fragrance Ingredients Without Animal Testing

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This article is Open Access under the terms of the Creative Commons CC BY-NC licence.

The determination of persistence (P), bioaccumulation (B) and toxicity (T) plays a central role in the environmental assessment of chemicals. Persistence is typically evaluated via standard microbial biodegradation tests. Bioaccumulation refers to the accumulation of chemicals in organisms and is usually assessed in fish exposed to the test chemical. Toxicity is determined at three trophic levels, with fish toxicity as the highest trophic level assessed. Thus, animal tests are classically needed for both B and T assessment. In vitro systems based on fish liver cells or liver S9 fractions ('RT-S9 assay') have been recently adopted by OECD to measure the biotransformation rates for the chemicals for B assessment. Biotransformation drives clearance from the body and reduces bioaccumulation. For T assessment, an assay based on in vitro toxicity on fish gill cells has been established ('RTgill-W1 assay'). Here we summarize our findings indicating that these tests are highly predictive for fragrance ingredients, and show with two case studies of our latest new registered substances how we apply these tests in particular during development and also for chemical registration. This platform of tests (PeBiToSens™) could fully replace animal tests in ecotoxicological assessment and is key in the Givaudan Safe by Design™ approach to develop safer and environmentally compatible novel fragrance ingredients.
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Keywords: ACUTE AQUATIC TOXICITY; BIOACCUMULATION; BIODEGRADATION; ECOTOXICITY; IN VITRO

Document Type: Research Article

Affiliations: 1: Fragrances S&T, Givaudan Schweiz AG, Kemptpark 50, CH-8310 Kemptthal, Switzerland;, Email: [email protected] 2: Fragrances S&T, Givaudan Schweiz AG, Kemptpark 50, CH-8310 Kemptthal, Switzerland 3: Regulatory Affairs and Product Safety, Givaudan International SA, 5, Chemin de la Parfumerie, CH-1214 Vernier, Switzerland 4: Fragrances S&T, Givaudan Schweiz AG, Kemptpark 50, CH-8310 Kemptthal, Switzerland;, Email: [email protected]

Publication date: March 1, 2020

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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