Skip to main content
padlock icon - secure page this page is secure

Open Access The Xanthate Route to Amino Acids

Download Article:
 Download
(PDF 558.6 kb)
 

This article is Open Access under the terms of the Creative Commons CC BY-NC licence.

The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, α, β, and γ-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and β-lactams. The radical addition furnishes naturally latent mercapto-α-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Keywords: AMINO ACIDS; NATIVE CHEMICAL LIGATION; RADICAL ADDITION; XANTHATES; β-LACTAMS

Document Type: Research Article

Affiliations: Laboratoire de Synthèse Organique, UMR 7652, Ecole Polytechnique, 91128 Palaiseau, France;, Email: [email protected]

Publication date: February 1, 2020

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more