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Episodes from the Continuous Search for Solutions against Downy Mildew Diseases

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Discovery background, lead optimization pathways, synthesis and structure–activity relationships of three different research projects searching for new active ingredients against downy mildew diseases are reported. These case studies, on which the author worked in three different decades in the research departments of Syngenta Crop Protection AG and its legacy company Novartis Crop Protection AG deal with inhibitors of cellulose synthase, tubulin polymerization and oxysterol-binding protein. Rarely used reactions, which have been applied within these projects, such as Seebach's variation of the Passerini reaction, the Bogert quinazoline synthesis and the carbonyldiimidazole-mediated Lossen rearrangement give proof of the significance of synthetic organic chemistry for modern crop protection.
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Document Type: Research Article

Affiliations: Syngenta Crop Protection AG, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein;, Email: [email protected]

Publication date: August 1, 2019

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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