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Open Access Interface-rich Aqueous Systems for Sustainable Chemical Synthesis

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Mimicking an enzyme's exquisite activity and selectivity is a long-standing goal for sustainable chemical method development in aqueous media. The use of interface-rich aqueous systems, such as single-chain polymers, micelles and vesicle membranes recently emerged as strategy to emulate the compartmentalization of natural systems. In aqueous solution, aggregates such as micelles or microemulsion droplets are formed, providing reaction environments different from bulk solutions that frequently improve selectivity and accelerate reaction rates for a wide array of chemical transformations. We present here selected examples of interface-rich aqueous systems and discuss the advantages they offer for chemical synthesis. In particular metal-catalyzed cross-coupling reactions are highlighted and future challenges to perform reactions in interface-rich aqueous media are discussed.

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Document Type: Research Article

Affiliations: 1: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel 2: Chemical & Analytical Development, Novartis Pharma AG, CH-4056 Basel 3: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel;, Email: [email protected] 4: Chemical & Analytical Development, Novartis Pharma AG, CH-4056 Basel;, Email: [email protected]

Publication date: September 1, 2019

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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