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Extracellular Vesicles and their miRNA Cargo: A Means of Communication between Soma and Germline in the Mammalian Reproductive System

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MicroRNAs (miRNAs) are small non-coding RNAs able to silence gene expression by RNA interference. They are present in cells but many are contained in extracellular vesicles (EVs) that can be released by cells in the circulation. Circulating EVs can encounter other cells in the body and deliver their miRNA cargo. This process enables long-range communication between different cells and has been proposed to play important physiological roles. One of these roles that remains less well studied is in the reproductive system. In ovaries and testes, constant communication between somatic cells and developing germ cells is necessary for their maturation and EVs have been proposed to contribute to this communication. EVs might also enable external factors derived from environmental exposure to reach gametes and keep a trace of exposure for the offspring.
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Document Type: Research Article

Publication date: May 1, 2019

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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