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Open Access Recent Advances in Bioorthogonal Reactions

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This article is Open Access under the terms of the Creative Commons CC BY-NC-ND licence.

The ability to selectively perform chemical reactions within living systems has transformed the field of Chemical Biology. These chemoselective processes have had a major scientific impact by enabling studies of cellular processes, producing tools for the ligations of large biomolecules, and advancing our ability to image or track small molecular changes such as posttranslational modifications. As more investigators become involved in the development and application of chemical reactions performed within complex biological settings, there have been a rising number of innovations that create improved tools and resources for understanding nature. This perspective highlights some recent achievements that show how innovation and creativity can provide new opportunities in this exciting and rapidly expanding area of chemical research.

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Keywords: BIOORTHOGONAL; CHEMICAL BIOLOGY; CHEMICAL REPORTER; CHEMOSELECTIVE; LIGATION

Document Type: Research Article

Affiliations: 1: Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich, SCS-DSM Award for best poster presentation in Chemical Biology 2: Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich 3: Laboratorium für Organische Chemie, ETH Zurich, D-CHAB, Vladimir-Prelog-Weg 3, CH-8093 Zürich;, Email: [email protected]

Publication date: April 1, 2019

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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