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Open Access Ruthenium Complexes with PYA Pincer Ligands for Catalytic Transfer Hydrogenation of Challenging Substrates

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Here we highlight the potential of a series of ruthenium complexes with tridentate N,N,N pincer-type ligands featuring two pyridylidene amide (PYA) moieties in the ligand skeleton. They were successfully applied in transfer hydrogenation of ketones and C=C double bonds. Rational ligand design was key for increasing the catalytic performance in the reduction of challenging substrates such as potentially chelating acetylpyridines. The specific reaction profiles indicate catalyst poisoning via imine coordination as well as N,O-bidentate coordination of the substrate or the product. Approaches to mitigate this inhibition are presented. Furthermore, these PYA pincer ruthenium complexes accomplish the selective reduction of the C=C over C=O bond of α,β-unsaturated ketones such as benzylideneacetone, while other α,β-unsaturated ketones such as trans-chalcone predominantly underwent oxidative C=C bond cleavage.

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Keywords: HOMOGENOUS CATALYSIS; LIGAND DESIGN; PYRIDYLIDENE AMIDES; TRANSFER HYDROGENATION

Document Type: Research Article

Affiliations: 1: Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, CH-3012 Bern, SCS-DSM Award for best poster presentation in Inorganic & Coordination Chemistry 2: Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, CH-3012 Bern;, Email: [email protected]

Publication date: April 1, 2019

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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