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Open Access H/D Exchange Using Hot Heavy Water

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Metal-catalyzed H/D exchange in hydrothermal deuterium oxide, performed in an autoclave using external heating or in a sealed glass tube under microwave irradiation, was shown to be an efficient method for preparing various deuterium-labeled compounds. Phosphonium salts for the Wittig reaction were deuterated at the α-position in the presence of MS 4A under microwave irradiation; primary alcohols and primary/secondary amines were deuterated at the α-position in the presence of ruthenium catalyst under microwave irradiation; metal-catalyzed direct C–H functionalizations on sp3 and sp2 carbon gave the corresponding fully deuterated products under hydrothermal conditions. These methods gave various deuterium-labelled compounds efficiently using D2O as a D-atom source.

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Keywords: H/D EXCHANGE; HYDROTHERMAL; MICROWAVES; PALLADIUM; PLATINUM; RUTHENIUM

Document Type: Research Article

Affiliations: 1: Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan;, Email: [email protected] 2: Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan 3: The Amgen Scholar (http://amgenscholars.com/university/kyoto-university) from Department of Chemistry, University of Mandalay University Drive, 73rd Street, Mandalay, Myanmar

Publication date: December 1, 2018

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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