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Modern Ligation Methods to Access Natural and Modified Proteins

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Proteins and peptides are gaining increasing interest as tools and targets in fundamental research and drug discovery. Growing research applications have prompted the need for methodologies that produce homogenous peptide and protein material. The development of efficient, chemoselective ligation reactions using unprotected peptide fragments presents a key solution for this challenging task. This review outlines modern ligation methods that enable the synthesis of both native, and also labelled or post-translationally modified peptides and proteins. The ligation methods herein discussed focus on the formation of the backbone amide bond.
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Keywords: CHEMOSELECTIVE LIGATION; NATIVE CHEMICAL LIGATION; PROTEIN MODIFICATION; PROTEIN SEMI-SYNTHESIS

Document Type: Research Article

Affiliations: 1: Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP) Campus Berlin-Buch Robert-Roessle-Str. 10, D-13125 Berlin, Humboldt-Universität zu Berlin Institut für Chemie Brook-Taylor-Str. 2, D-12489 Berlin 2: Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP) Campus Berlin-Buch Robert-Roessle-Str. 10, D-13125 Berlin, Humboldt-Universität zu Berlin Institut für Chemie Brook-Taylor-Str. 2, D-12489 Berlin;, Email: [email protected]

Publication date: 01 November 2018

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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