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Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research

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Photo-cross-linkers are invaluable tools for identifying drug targets and off-targets as well as probing the binding sites in medicinal chemistry and chemical biology. In this review, we summarize recent development of the ligand-based and genetically encoded photo-cross-linkers and their use in biological system. In particular, we highlight our discovery of 2-aryl-5-carboxytetrazole (ACT) as a novel class of photo-cross-linkers and their successful applications in drug target identification as well as identifying transient protein–protein interaction complexes in mammalian cells.
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Keywords: GENETIC ENCODING; PHOTO-AFFINITY PROBE; PHOTO-CROSS-LINKER; PROTEIN–PROTEIN INTERACTION; TARGET IDENTIFICATION

Document Type: Research Article

Affiliations: 1: 679 Natural Science Complex Department of Chemistry State University of New York at Buffalo Buffalo, New York 14260, USA 2: 679 Natural Science Complex Department of Chemistry State University of New York at Buffalo Buffalo, New York 14260, USA;, Email: [email protected]

Publication date: 01 November 2018

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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