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Open Access Sunlight-driven Environmental Benign Production of Bioactive Natural Products with Focus on Diterpenoids and the Pathways Involved in their Formation

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Diterpenoids are high value compounds characterized by high structural complexity. They constitute the largest class of specialized metabolites produced by plants. Diterpenoids are flexible molecules able to engage in specific binding to drug targets like receptors and transporters. In this review we provide an account on how the complex pathways for diterpenoids may be elucidated. Following plant pathway discovery, the compounds may be produced in heterologous hosts like yeasts and E. coli. Environmentally contained production in photosynthetic cells like cyanobacteria, green algae or mosses are envisioned as the ultimate future production system.
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Keywords: ALCOHOL DEHYDROGENASES; CYTOCHROME P450S; INGENOL MEBUTATE; LIGHT-DRIVEN PRODUCTION; TERPENE SYNTHASES

Document Type: Research Article

Affiliations: 1: Plant Biochemistry Laboratory Center for Synthetic Biology Department of Plant and Environmental Sciences University of Copenhagen, Thorvaldsensvej 40 DK-1871 Frederiksberg C, Copenhagen, Denmark 2: Plant Biochemistry Laboratory Center for Synthetic Biology Department of Plant and Environmental Sciences University of Copenhagen, Thorvaldsensvej 40 DK-1871 Frederiksberg C, Copenhagen, Denmark;, Email: [email protected]

Publication date: 01 December 2017

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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