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Open Access Investigating the Structure–Activity Relationship of the Insecticidal Natural Product Rocaglamide

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The natural product Rocaglamide (1), isolated from the tree Aglaia elliptifolia, is a compelling but also challenging lead structure for crop protection. In laboratory assays, the natural product shows highly interesting insecticidal activity against chewing pests and beetles, but also phytotoxicity on some crop plants. Multi-step syntheses with control of stereochemistry were required to probe the structure–activity relationship (SAR), and seek simplified analogues. After a significant research effort, just two areas of the molecule were identified which allow modification whilst maintaining activity, as will be highlighted in this paper.
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Keywords: INSECTICIDE; ROCAGLAMIDE; STRUCTURE–ACTIVITY RELATIONSHIP

Document Type: Research Article

Affiliations: 1: Syngenta Crop Protection AG Research Chemistry WST-810.3.18 CH-4332 Stein;, Email: [email protected] 2: Formerly Ciba Central Research, later Novartis Central Research laboratories, Macclesfield, UK 3: Syngenta Crop Protection AG Research Chemistry WST-810.3.18 CH-4332 Stein 4: Formerly Novartis Crop Protection, Basel, Switzerland

Publication date: 01 December 2017

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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