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Open Access Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer

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Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.
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Keywords: BURULI ULCER; DIVERTED TOTAL SYNTHESIS; MYCOLACTONE; TOTAL SYNTHESIS

Document Type: Research Article

Affiliations: 1: Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France 2: Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France;, Email: [email protected]

Publication date: 01 December 2017

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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