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Open Access Strategies and Tactics for the Synthesis of Complex Alkaloids

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Efforts to achieve the laboratory synthesis of complex natural products have long served as a means to advance the science of organic chemistry. Indeed, core physical organic principles, new reagents and synthetic transformations, effective strategies for stereocontrolled synthesis, and useful pharmaceutical agents are but a few advances that have issued from such endeavors over the course of the past century. Within this review are recounted selected research programs from the author's laboratory seeking to add to that repertoire of discoveries by targeting complex polycyclic alkaloids for synthesis. Advances resulting from these studies include new strategies for the rapid synthesis of intricate molecular domains, reaction processes and sequences capable of accessing a range of diversity across several alkaloid classes, examples of achieving family-level synthetic solutions from common synthetic building blocks, and a unique perspective on effecting the laboratory synthesis of dimeric materials when direct mergers fail.
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Document Type: Research Article

Affiliations: Department of Chemistry University of Chicago 5735 S. Ellis Avenue, Chicago, IL 60637, USA;, Email: [email protected]

Publication date: 01 December 2017

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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