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Open Access Inflammasomes in Host Defense and Autoimmunity

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Inflammasomes are large multi-protein complexes that control host defense and inflammation during infections with pathogens. Their clinical importance however reaches beyond infectious disease, since dysregulated inflammasome activity has also been linked to many auto-inflammatory disorders. This article gives a short overview on the basics of inflammasome signaling, their activation mechanisms and their role in autoimmunity.

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Keywords: AUTOIMMUNITY; INFECTIOUS DISEASES; INFLAMMASOMES; INFLAMMATION; INNATE IMMUNITY

Document Type: Research Article

Affiliations: Biozentrum University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland. [email protected]

Publication date: 01 December 2016

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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