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Open Access Transition Metal-free Methylation of Amines with Formaldehyde as the Reductant and Methyl Source

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A simple transition metal-free procedure using formal dehyde for the N,N-dimethylation and N-methylation of primary and secondary anilines is reported. The reaction showed limitations on sterically hindered and electron-withdrawing anilines, but is successful on amines with electron-donating substituents. Formaldehyde acts as both the reducing agent and the carbon source in the reaction.

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Keywords: ANILINES; ESCHWEILER-CLARKE REACTION; FORMALDEHYDE; METAL-FREE; N-METHYLATION

Document Type: Research Article

Affiliations: 1: School of Chemistry and Biochemistry The University of Western Australia 35 Stirling Hwy, Crawley WA 6009, Australia 2: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a 18059 Rostock, Germany 3: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a 18059 Rostock, Germany. [email protected]

Publication date: 01 June 2015

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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