Skip to main content
padlock icon - secure page this page is secure

Open Access Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers

Download Article:
 Download
(PDF 331.1 kb)
 
A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of exploring the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg intravenously on experimental pain models. Further, the simplified UVB model was validated as a screening tool for analgesics or a combination of analgesics in clinical drug development. It was observed that the UVB irradiation induced primary hyperalgesia, evidenced by significant decreases of the heat pain threshold from (mean ± SD) 46.9 ± 1.1 °C to 40.1 ± 1.7 °C (p <0.001) and of the mechanical pain threshold (62% decrease). A small intra- and inter-individual variability was observed as well as consistent intra-day stability for the heat pain threshold. The UVB irradiation also resulted in the development of an area of secondary hyperalgesia of 21.3 ± 11.3 cm2. The mechanical pain threshold and area of secondary hyperalgesia showed small intra-individual variability and consistent intra-day stability. However, a greater variability was observed between subjects, which suggests that a crossover design would allow limiting the number of subjects.

21 References.

No Supplementary Data.
No Article Media
No Metrics

Keywords: ANALGESICS COMBINATION; NSAIDS; PARACETAMOL; UVB; VARIABILITY

Document Type: Research Article

Affiliations: 1: Division of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland 2: Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland; Division of Dermatology and Venerology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland 3: Division of clinical pharmacology and toxicology University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4, CH-1211 Geneva, Switzerland; Faculty of Medicine University of Geneva 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland. [email protected]

Publication date: 01 May 2012

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more