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Open Access Cu(i)/Amino Acid Catalyzed Coupling Reactions of Aryl Halides and Nucleophiles: Applications in Large-scale Production

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Amino acids can be used as ligands to promote Ullmann-type coupling reactions. This review briefly discusses how L-proline, 4-hydroxy-L-proline and N,N-dimethylglycine can serve as the ideal ligands for copper-catalyzed coupling of aryl halides with different nucleophiles. Seven examples of applications of copper/amino acid catalyzed reactions in large-scale preparations are described.

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Keywords: COPPER-CATALYZED COUPLING REACTIONS; L-PROLINE; ULLMANN-TYPE COUPLING REACTIONS

Document Type: Research Article

Affiliations: 1: State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 LingLing Road Shanghai 200032, China. [email protected] 2: State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 LingLing Road Shanghai 200032, China

Publication date: 01 December 2011

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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