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Open Access Thermal Cleavage of the Fmoc Protection Group

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The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.

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Keywords: DIBENZOFULVENE; FMOC PROTECTION GROUP; HIGH-TEMPERATURE NMR; PEPTIDE SYNTHESIS; THERMAL CLEAVAGE

Document Type: Miscellaneous

Affiliations: 1: ZHAW Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry (ICBC), Campus Reidbach, Einsiedlerstrasse 31, CH-8820 Wädenswil 2: Ecole d'Ingénieurs et d'Architectes de Fribourg, Département des Technologies Industrielles, Filière de Chimie, Bd de Pérolles 80, CH-1705 Fribourg 3: Part of MS's Bachelor thesis; Empa Dübendorf, Überlandstrasse 129, CH-8600 Dübendorf

Publication date: 01 March 2010

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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