Skip to main content
padlock icon - secure page this page is secure

Open Access In situ Product Recovery Integrated with Biotransformations

Download Article:
(PDF 143.4 kb)
Biocatalysis constitutes an effective tool for the production of fine chemicals. In order to widen the spectrum of applicable reaction types to reactions that are constrained by inhibitions, product toxicity, or degradation, an unfavorable position of the thermodynamic equilibrium, or by kinetic control, in situ product removal (ISPR) is an attractive process option to overcome those limitations. To fully exploit the benefits of the ISPR approach, selective removal of the product to an auxiliary phase with high capacity is usually required. Obviously, such an operation becomes increasingly difficult with decreasing differences in the physical properties of substrate(s) and product(s) as it is arguably frequently the case with biotransformations. In this paper we analyze the possibilities to apply ISPR to biotransformations and identify the most promising developments supported by simple model considerations to fully exploit the potential of ISPR.

82 References.

No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: June 1, 2009

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more