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Open Access The Synthetic-Technical Development of Oseltamivir Phosphate Tamiflu: A Race against Time

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The clinical development of the first orally available neuraminidase inhibitor prodrug oseltamivir phosphate (Tamiflu) proceeded very fast. In order to support this program an unprecedented team effort in chemical process research, development, piloting, production and analytics took place, which allowed the successful launch of Tamiflu in 1999, only two and a half years after it was licensed from Gilead Sciences. This article describes selected aspects of the commercially used synthesis route and a brief summary of alternative syntheses devised by Roche chemists.

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Keywords: ANALYTICS; INFLUENZA NEURAMINIDASE INHIBITOR; OSELTAMIVIR PHOSPHATE; PRODUCTION; SYNTHESIS; TECHNICAL DEVELOPMENT

Document Type: Research Article

Publication date: March 1, 2007

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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