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The role of non-steroidal anti-inflammatory drugs for the treatment of delayed onset muscle soreness in sport : review article

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Objective : To investigate the efficacy of non-steroidal anti-inflammatory drugs for the treatment of delayed onset muscle soreness. Data sources : PubMed and SPORTDiscus databases were searched from January 12-30, 2004 for the following terms: delayed onset muscle soreness, DOMS, exercise induced/associated muscle damage/soreness, contraction induced muscle damage/soreness, muscle injury, muscle soreness, non-steroidal anti-inflammatory drugs, aspirin, diclofenac, flurbiprofen, ibuprofen, ketoprofen, and naproxen. Study section : Inclusion criteria were use of human subjects and placebo-controlled design. Data extraction : Information relevant to specific drug studied, dosing, method of inducing DOMS, measurements used, and outcome were used. Data synthesis : Studies with primary findings supporting and refuting the use of NSAIDs for the treatment of DOMS are individually discussed. Conclusions : Due to potential adverse effects and inconclusive evidence, it is our opinion that the routine recommendation of NSAIDs for the treatment of DOMS is not warranted.
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Keywords: Exercise-induced muscle soreness; Indiana State University; Inflammation; Muscle injury; NSAIDs; Pharmacology; Therapeutic modality; University of Virginia

Document Type: Research Article

Publication date: January 1, 2004

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