Familial sinistrality and handedness in patients with first episode schizophrenia: The EUFEST study
The population with schizophrenia is characterised by a leftward shift in handedness—sinistrality. However, findings are inconsistent in chronic patients, and familial sinistrality (FS), defined as the presence of left-handed close relatives, might contribute to the discrepancies.
Therefore the aim of this study was to investigate the strength of manual lateralisation in patients with first episode schizophrenia, taking into account familial sinistrality. The Edinburgh Inventory (EI) allowed us to categorise 179 patients from the EUFEST study and 189 controls presenting
“strong handedness” (SH: EI absolute value between ∣81∣ and ∣100∣) or “weak-handedness” (WH: EI value between −80 and +80). The nominal logistic regression did not show an FS effect, but a nearly significant interaction between illness and FS (p
=.07). There were fewer participants without FS presenting SH among patients (99/151: 65.6%) than among controls (134/164: 81.7%, p =.001). In contrast, the number of participants with FS presenting SH was similar between controls (68%) and patients (75%, p =.57). The presence
of left-handed relatives (FS + ) tended to reduce manual lateralisation, but only in controls. This supports the notion that reduced manual lateralisation in schizophrenia is related to the illness rather than to familial left-handedness.
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First psychotic episode;
Document Type: Research Article
Department of Psychiatry, Centre Esquirol, Centre Hospitalier Universitaire, Caen, France
UMR 6232, CNRS, CEA, Universités Caen Paris René Descartes, France
Department of Psychiatry, Al. Obregia Psychiatric Hospital, Bucharest, Romania
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
Sheba Medical Center, Tel Hashomer, Israel
Department of Psychiatry, University of Naples SUN, Naples, Italy
Department and Clinic of Psychiatry, Charles University Medical School and Faculty Hospital, Hradec Králové, Czech Republic
Department and Clinic of Psychiatry, University Hospital of Neurology and Psychiatry St Naum, Sofıa, Bulgaria
Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
Department of Epidemiology, University Medical Centre Groningen, The Netherlands
University Psychiatric Centre, Campus St. Jozef Kortenberg, Katholieke Universiteit Leuven, Leuven, Belgium
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
March 1, 2012