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Effect of erectile dysfunction medications on coexisting sexual dysfunctions in couples: Partners' Preference Study

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There is sparse information on how treatments for erectile dysfunction (ED) affects couples. This study investigated the effects of ED treatments on 100 heterosexual couples' sexual functioning and whether function achieved using a short-acting versus a long-acting ED medication differed significantly. Couples were randomized to use tadalafil or sildenafil for each of two 12-week study phases; they completed questionnaires (International Index of Sexual Function and Female Sexual Function Index) and kept sexual event diaries. All participants experienced significant improvements over baseline sexual functioning, while the men used short- or long-acting ED medications with no significant differences related to the duration of drug action recorded for either the men or women. Despite this lack of difference in efficacy there was a strong preference by women (79%) and their partners (16%) for the longer-acting medication. The reasons for this warrant further investigation. Understanding the effects on couples of the use of ED medications is a necessary aspect of ensuring ongoing sexual satisfaction in couples treated for ED.
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Keywords: Female Sexual Function Index; International Index of Erectile Function; PDEV inhibitors; couples; phosphodiesterase type 5 inhibitors; sexual dysfunction; sildenafil; tadalafil

Document Type: Research Article

Affiliations: 1: Deakin University, Melbourne, Australia 2: Accident Research Centre, Monash University, Melbourne, Australia 3: Waikato Clinical School, Faculty of Medical & Health Sciences, University of Auckland, Hamilton, New Zealand

Publication date: August 1, 2009

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