Influence of chitosan-based dressing on prevention of synechia and wound healing after endoscopic sinus surgery: A meta-analysis
Introduction:
Endoscopic sinus surgery (ESS) has had many complications, e.g., synechia formation. This meta-analysis investigated the effect of a novel chitosan-based dressing on prevention of synechia and wound healing after ESS.
Methods:
We systematically searched various medical literature data bases and included the randomized controlled trials (RCT) regarding the effect of novel chitosan-based dressing on ESS. The study outcomes included synechia, granulations, hemostasis, crusting scores, and infection.
Results:
Six RCTs, which involved 337 patients, were included in the meta-analysis. Compared with control intervention after ESS, chitosan-based gel dressing substantially inhibited synechia (risk ratio [RR] 0.28 [95% confidence interval {CI}, 0.15‐0.54]; p = 0.0001), improved granulations (RR 1.47 [95% CI, 1.07‐2.03]; p = 0.02), and hemostasis (RR 1.47 [95% CI, 1.07‐2.03]; p = 0.02) but demonstrated no effect on crusting scores (standard mean difference −0.41 [95% CI, −1.06 to 0.23]; p = 0.21) and infection (RR 0.88 [95% CI, 0.51‐1.52]; p = 0.64).
Conclusion:
Compared with control intervention, chitosan-based dressing was associated with significantly reduced synechia and with increased granulations and hemostasis but showed no influence on crusting and infection after ESS.
Endoscopic sinus surgery (ESS) has had many complications, e.g., synechia formation. This meta-analysis investigated the effect of a novel chitosan-based dressing on prevention of synechia and wound healing after ESS.
Methods:
We systematically searched various medical literature data bases and included the randomized controlled trials (RCT) regarding the effect of novel chitosan-based dressing on ESS. The study outcomes included synechia, granulations, hemostasis, crusting scores, and infection.
Results:
Six RCTs, which involved 337 patients, were included in the meta-analysis. Compared with control intervention after ESS, chitosan-based gel dressing substantially inhibited synechia (risk ratio [RR] 0.28 [95% confidence interval {CI}, 0.15‐0.54]; p = 0.0001), improved granulations (RR 1.47 [95% CI, 1.07‐2.03]; p = 0.02), and hemostasis (RR 1.47 [95% CI, 1.07‐2.03]; p = 0.02) but demonstrated no effect on crusting scores (standard mean difference −0.41 [95% CI, −1.06 to 0.23]; p = 0.21) and infection (RR 0.88 [95% CI, 0.51‐1.52]; p = 0.64).
Conclusion:
Compared with control intervention, chitosan-based dressing was associated with significantly reduced synechia and with increased granulations and hemostasis but showed no influence on crusting and infection after ESS.
Keywords: Chitosan-based dressing; endoscopic sinus surgery; meta-analysis; synechia; systematic review
Document Type: Research Article
Affiliations: Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
Publication date: 01 November 2017
This article was made available online on 04 August 2017 as a Fast Track article with title: "Influence of chitosan-based dressing on prevention of synechia and wound healing after endoscopic sinus surgery:A meta-analysis ".
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content