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A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia

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Mycobacterium avium complex (MAC) infections, generally viewed as opportunistic infections, often trigger an evaluation for an underlying immunodeficiency disorder. However, MAC infections can occur in patients who presumably are immunocompetent, particularly in those with an underlying structural lung disease. T-cell immunity plays a critical role in controlling MAC infection. We presented a case of lymphopenia, which complicated the clinical course of a pulmonary MAC infection in a patient who was negative for human immunodeficiency virus.
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Keywords: Rifamycins; Th1 polarization; abnormal mitogen study; idiopathic CD4 lymphopenia; lymphocyte redistribution; lymphopenia; pulmonary mycobacterial avium complex infection; rifabutin; rifampin; secondary immunodeficiency

Document Type: Research Article

Affiliations: 1: From the Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 2: Department of Pediatrics, University of Washington, Seattle, Washington, and

Publication date: January 1, 2020

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