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Noninfectious complications of common variable immune deficiency

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Common variable immune deficiency (CVID) is a primary immune deficiency due to defective B-cell maturation.


To improve recognition of noninfectious complications of CVID and increase awareness of appropriate interventions for noninfectious complications of CVID.


To review the diagnosis and treatment of CVID with infectious and noninfectious complications.


A case of a woman with CVID with autoimmunity and gastrointestinal complications is presented with a discussion of the recognition and treatment of infectious and noninfectious complications.


Patients with CVID must be monitored for noninfectious complications, e.g., inflammatory disease of the lung and gastrointestinal tract, because these are associated with decreased survival.
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Keywords: Autoimmunity; GLILD; T cell; common variable immune deficiency; enteropathy; immune deficiency; inflammatory bowel disease; malignancy; norovirus

Document Type: Research Article

Publication date: March 1, 2019

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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