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Pearls and pitfalls of food challenges in infants

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An oral food challenge (OFC) is considered the diagnostic criterion standard procedure for evaluation of a suspected food allergy in patients of any age. This can be accomplished as either an open or a blinded challenge. In recent years, the open OFC has become an acceptable and practical office-based practice. With the advent of new early peanut introduction guidelines, there is a critical need to potentially perform OFC in very young infants between the ages of 4 and 12 months of life. Experience from multiple recent randomized controlled clinical trials indicates that such OFCs are both safe and feasible, although the extent to which providers in the clinical setting are comfortable and experienced with OFCs in this population is unclear. This review detailed the essential features of performing an OFC in an infant to help guide the practicing allergist in how to set up his or her office and best accomplish this very important procedure.
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Keywords: Peanut allergy; anaphylaxis; epinephrine; infants; oral food challenge

Document Type: Research Article

Publication date: January 1, 2019

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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