Drug-induced eosinophilia
Background:
Drug reactions have been associated with increased blood eosinophil levels.
Objective:
To review clinical characteristics, the diagnosis, and the management of drug-induced eosinophilia.
Methods:
Pertinent articles were selected and reviewed in relation to a case presentation of drug-induced eosinophilia.
Results:
A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia. Clinical pearls and pitfalls were reviewed for the practicing allergist, clinical immunologist, and fellow-in-training.
Conclusion:
Drug-induced eosinophilia is a diagnosis of exclusion. Although most cases of drug-induced eosinophilia are asymptomatic, one study showed an increased rate of hypersensitivity reactions in patients with higher eosinophil counts and earlier onset of eosinophilia.
Drug reactions have been associated with increased blood eosinophil levels.
Objective:
To review clinical characteristics, the diagnosis, and the management of drug-induced eosinophilia.
Methods:
Pertinent articles were selected and reviewed in relation to a case presentation of drug-induced eosinophilia.
Results:
A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia. Clinical pearls and pitfalls were reviewed for the practicing allergist, clinical immunologist, and fellow-in-training.
Conclusion:
Drug-induced eosinophilia is a diagnosis of exclusion. Although most cases of drug-induced eosinophilia are asymptomatic, one study showed an increased rate of hypersensitivity reactions in patients with higher eosinophil counts and earlier onset of eosinophilia.
Document Type: Research Article
Affiliations: 1: From the Department of Hospital Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania 2: Department of Allergy and Immunology, Allegheny Health Network, Pittsburgh, Pennsylvania
Publication date: 01 May 2018
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