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The effect of allergen-specific immunotherapy on offspring

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The incidence of allergic diseases has increased worldwide. Thus, there is a need for effective primary prevention of allergies.


The aim of the present study was to examine how allergen-specific immunotherapy (ASIT) affects the development of allergies in the generation of children whose parents were subjected to this method of treatment.


A total of 194 children with at least one parent with allergy subjected to ASIT were enrolled. These patients were compared with control individuals without ASIT. Their risk of allergy, based on medical history, examination, allergy skin-prick tests, serum total immunoglobulin E and specific immunoglobulin E concentrations was assessed.


The children of parents subjected to immunotherapy showed significantly reduced clinical symptoms of allergic disease. The odds ratios (OR) of any allergic disease and asthma were significantly lower in children with one or both parents with allergy after ASIT compared with the children with parents with allergy and without ASIT: OR 0.73 (95% confidence interval [CI], 0.59‐0.86) versus OR 1.85 (95% CI, 1.73‐2.2) for any allergic disease and OR 0.63 (95% CI, 0.53‐0.79) versus OR 1.36 (95% CI, 1.22‐1.67) for asthma.


The phenomenon of reducing the risk of allergies in children whose parents were desensitized might be important in the primary prevention of allergies.
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Keywords: IgE; Immunotherapy; allergen; allergic rhinitis; allergy; asthma; atopic dermatitis; mites; pollens; prevention; skin prick test

Document Type: Research Article

Affiliations: Clinical Department of Internal Diseases, Dermatology and Allergology, Medical University of Silesia, Zabrze, Poland

Publication date: July 1, 2016

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. AAP welcomes the submission of original works including peer-reviewed original research and clinical trial results. Additionally, as the official journal of the Eastern Allergy Conference (EAC), AAP will publish content from EAC poster sessions as well as review articles derived from EAC lectures.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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