Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Lang, David M.
TI - Severe asthma: Epidemiology, burden of illness, and heterogeneity
JO - Allergy and Asthma Proceedings
PY - 2015-11-01T00:00:00///
VL - 36
IS - 6
SP - 418
EP - 424
KW - asthma heterogeneity
KW - asthma severity
KW - Asthma
KW - asthma control
N2 -
Background:
Patients with severe persistent asthma comprise only 5‐10 % of the total asthma population, but account for a large proportion of asthma morbidity and health care expenditures. Among patients with severe asthma, higher costs can be expected in association
with not well or poorly controlled asthma.
Objective:
To summarize the evidence concerning the epidemiology, burden, and heterogeneity of severe asthma.
Methods:
A literature search was performed to identify citations using the terms “severe asthma”
and “epidemiology”, “asthma control”, “asthma” and “heterogeneity”.
Results:
Successful management of patients with severe asthma continues to be a major unmet need. One of the barriers to successful management is the heterogeneity
of asthma. Asthma is not one disease; it is a disorder that can be subdivided into a number of different phenotypes and endotypes. A revised paradigm for asthma management, that entails categorization of asthma patients via use of “biomarkers”, and prescribing targeted therapy,
will supplant what has been a “one size fits all” approach to asthma management.
Conclusion:
The novel approach to asthma management, in which therapy will be more mechanism-specific based on phenotype/endotype, offers the potential for improved asthma care
outcomes ‐ particularly for patients with severe persistent asthma who are not well or poorly controlled.
UR - https://www.ingentaconnect.com/content/ocean/aap/2015/00000036/00000006/art00008
M3 - doi:10.2500/aap.2015.36.3908
UR - https://doi.org/10.2500/aap.2015.36.3908
ER -