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Atopic keratoconjunctivitis

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Atopic keratoconjunctivitis (AKC) is a chronic allergic inflammatory disease that is at the severe end of a spectrum of allergic conjunctival diseases. AKC can involve the cornea and conjunctiva bilaterally, and at times can lead to visual loss from corneal complications. The classification, histology, ocular examination findings and complications of AKC are described herein, as well as the roles and interactions of inflammatory cells involved. Finally, current treatment options for AKC is reviewed and presented as a stepwise, multidisciplinary approach that involves the allergist/immunologist's medical interventions of topical and systemic immunomodulating agents, as well as the surgical skills of the ophthalmologist.
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Keywords: Allergic conjunctivitis; Th2 cells; atopic keratoconjunctivitis; blepharoconjunctivitis; corneal diseases; cyclosporine; mast cells; ocular allergy; tacrolimus

Document Type: Research Article

Affiliations: Department of Medicine, Atlantic Health System, Overlook Medical Center, Summit, New Jersey, USA

Publication date: January 1, 2013

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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