@article {Ciprandi:2012:1088-5412:e5,
title = "A forced expiratory flow at 2575% value <65% of predicted should be considered abnormal: A real-world, cross-sectional study",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2012",
volume = "33",
number = "1",
publication date ="2012-01-01T00:00:00",
pages = "e5-e8",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2012/00000033/00000001/art00003",
doi = "doi:10.2500/aap.2012.33.3524",
keyword = "spirometry, FEF25‐75, children, FEV1, cutoff, Allergic asthma",
author = "Ciprandi, Giorgio and Capasso, Michele and Tosca, Mariangela and Salpietro, Carmelo and Salpietro, Annamaria and Marseglia, Gianluigi and La Rosa, Mario",
abstract = "Forced expiratory volume in 1 second (FEV1) is considered an important parameter for asthma diagnosis and follow-up. However, it has been proposed that forced expiratory flow at 2575% (FEF2575) could be more sensitive than FEV1 to detect
slight airways obstruction. In this regard, a cutoff FEF2575 value has been recently established in a group of asthmatic children: FEF2575 < 65% of predicted has been considered impaired. However, the considered population was specifically selected.
Therefore, the aim of the present study was to confirm an FEF2575 cutoff value in a large cohort of asthmatic children. Seven hundred allergic children (493 male subjects; median age, 11 years) with controlled and partly controlled asthma were evaluated by performing spirometry
and skin-prick tests. Three hundred thirteen (44.7%) patients had FEF2575% values of 2575 values: (i) sensitization to perennial allergens (adjusted odds ratio [ORAdj],
3.4) and (ii) FEV1 86% of predicted (ORAdj, 3.8). This study, conducted in real life, could suggest that FEF2575 value of <65% of predicted may be considered abnormal.",
}