@article {Kurt:2010:1088-5412:126,
title = "The effects of natural pollen exposure on inflammatory cytokines and their relationship with nonspecific bronchial hyperresponsiveness in seasonal allergic rhinitis",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2010",
volume = "31",
number = "2",
publication date ="2010-03-01T00:00:00",
pages = "126-131",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2010/00000031/00000002/art00010",
doi = "doi:10.2500/aap.2010.31.3325",
keyword = "pollen, seasonal allergic rhinitis, Allergic rhinitis, bronchial provocation test, bronchial hyperresponsiveness, rhinitis, cytokine",
author = "Kurt, Emel and Aktas, Ayse and Gulbas, Zafer and Erginel, Sinan and Arslan, Sertac",
abstract = "The exact mechanism of bronchial hyperresponsiveness (BHR) is not clear in allergic rhinitis (AR); an increase of BHR in pollen season suggests that natural pollen exposure causes airway inflammation in seasonal AR (SAR). This study was designed to investigate the effects of natural pollen exposure on inflammatory cytokines and their relationship with BHR. Sixty-six SAR patients with grass pollen sensitivity and 26 nonallergic rhinitis (NAR) patients were included. Peripheral blood samples for cytokine levels were taken and a nonspecific bronchial provocation test was performed during pollen season between May and August. The same measurements were repeated off-season between November and February. These measurements were done in NAR patients once. During the pollen season, SAR patients had significantly more increased levels of IL-13 than NAR patients (11.45 \textpm 12.54 versus 5.19 \textpm 4.02; p = 0.005). Blood eosinophil numbers were higher in those patients with BHR during pollen season than those without BHR (399.0 \textpm 255.8 versus 278.9 \textpm 193.2 mm3; p = 0.046). Blood eosinophil numbers during off-season were not different in those with and without BHR (respectively, 261.4 \textpm 202.3 mm3 versus 205.9 \textpm 116.9 mm3; p = 0.53). IL-10 levels were higher in the patients without BHR (n = 28) than those patients with BHR (n = 22) during off-season (8.12 \textpm 13.1 versus 3.28 \textpm 0.37; p = 0.04). Having higher levels of IL-10 than threshold value was more frequent in SAR patients without BHR than those patients with BHR during off-season (7/28 versus 1/22; 2 = 4.34; p = 0.04). IL-10 has a role in the continuation of BHR during off-season in SAR patients.",
}